Alterations in Cellular Metabolis
weakness / stiffness / laryngeal
paralysis / facial paralysis / tragic expression / knuckling or dragging feet / muscle wasting / megaesophagus / head tilt
/ drooping eyelids
Neuromuscular Problems
seizures / mental dullness / exercise
intolerance / neurologic signs polyneuropathy / lethargy / weight gain / cold intolerance / mood swings hyperexcitability
/ stunted growth / chronic infections
Dermatologic Diseases
dry, scaly skin and dandruff /
coarse, dull coat / bilateral symmetrical hair loss / rat tail, puppy coat / hyperpigmentation / seborrhea or greasy skin
pyoderma or skin infections / myxedema / chronic offensive skin odor
Reproductive
Disorders
infertility of either sex / lack
of libido / testicular atrophy / hypospermia aspermia / prolonged interestrus interval / absence of heat cycles / silent heats
/ pseudopregnancy / weak, dying or stillborn pups
Cardiac Abnormalities
slow heart rate (bradycardia) /
cardiac arrhythmias / cardiomyopathys
Gastrointestinal Disorders
constipation / diarrhea / vomiting
Hematological
Disorders
bleeding / bone marrow failure
/ low red blood cells / low white blood cells / low platelets
Ocular Diseases
corneal lipid deposits / corneal
ulceration / uveitis Keratococonjunctivitis / sicca or dry eye / infections of eyelid glands (Meibomian gland)
Temperament Issues
Unexplained aggression
Other Associated Disorders
lgA deficiency / loss of smell
(dysosmia) / loss of taste / glycosuria / chronic active hepatitis / other endocrinopathies adrenal, pancreatic, parathyroid